New GSU Research: Pyruvate Kinase M2 and Tumor Development

Closeup of a slide on a microscope

Image courtesy of _longpham on Flickr. (CC BY -NC 2.0)

Check out this new publication by current and former GSU graduate students Xueliang Gao, Haizhen Wang, and Xiaowei Liu; Chemistry professor Jenny J. Yang; and Biology professor Zhi-Ren Liu:

Gao et al., Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase, Molecular Cell (2012), doi:10.1016/j.molcel.2012.01.001

Their research examines the enzyme pyruvate kinase isoform M2 (PMK2) and its role in tumor development. The reported experiments suggest that PMK2 may be behind the activation of transcription activator stat3, seen in almost all types of cancer; the question of how cancer cells continuously activate stat3 has been a long-standing question in cancer research, and PMK2 may be the answer.

To read more on PMK2, take a look at articles in our Discover service.

About Jaclyn K Werner

Jackie Werner is the GSU Chemistry, Mathematics & Statistics, and Physics & Astronomy librarian.
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